Endocrine Abstracts

Aim: To evaluate the efficacy and safety for first patients treated in our clinic with liraglutide.Methods: Retrospective study of patients who started treatment with liraglutide in the last year in our department. We collected data on age, years of evolution, chronic complications, previous treatment, physical examination, analytical parameters and side effects.Results: Fifty-four patients. Follow-up: 4–12 months. Mean age: 5...

Hypophysitis are a heterogeneous group of inflammatory lesions affecting the hypophysis. Have been described hypophysitis secondary to administration of immunomodulatory drugs such as interferon and anti-cytotoxic T lymphocyte antigen-4 antibodies (CTLA-4). Ipilimumab is an anti-CTLA-4 human monoclonal antibody that blocks the union between CTLA-4 and B7 receptor on antigen-presenting cells causing an antitumoral effect and increasing the production of autoantibodies. Hypophys...

Introduction: Cushing disease (CD) results from excessive exposure to glucocorticoids caused by an adrenocorticotropic hormone–secreting pituitary tumor. Inadequately treated CD is associated with significant morbidity and elevated mortality.Objetive: The study purpose was to describe the long term treatment outcomes for CD patients in our hospital.Methods: Retrospective analysis of the records of 36 patients with Cushing dise...

Introduction: The clinical presentation of ectopic Cushing’s syndrome secondary to pheochromocytoma differs from the classic manifestations of these endocrinopathies separately. This cosecretion causes greater morbidity, requiring a complex preoperative preparation. We describe two clinical cases, a 46-year-old male with grade II overweight and a 65-year-old female with grade I obesity, both with a personal history of hypertension poorly controlled with 7 and 3 antihypert...

Introduction: Hydroxymethylglutaric aciduria is a rare metabolic disease that is caused by the deficiency of the enzyme 3-hydroxy-3-methylglutaryl-CoA lyase, which participates in the metabolism of leucine and in the formation of ketone bodies. The symptomatology usually occurs in the first two years of life and consists of nausea, vomiting, diarrhea, hypotoniaanddepressed level of consciousness. Metabolic acidosis occurs during crises as a result of the accumulation of metabo...

Background and aims: To assess the relationship between 25-hydroxyvitaminD levels and prevalence and incidence of metabolic syndrome.Methods: We undertook a population-based cohort study in Spain. At baseline (1996–1998), 1226 subjects were evaluated. Follow-up visits were performed in 2002–2004 and 2005–2007. At baseline and follow-up, participants underwent an interview and a standardized clinical examination with an oral glucose toleran...

Introduction: Thyroid ultrasound is a widely used tool in monitoring thyroid nodule, allowing us to assess the size and other sonographic signs suspicious of malignancy, facilitating decisions about diagnosis and treatment.Objectives: To evaluate the presence of ultrasonographic signs suggestive of malignancy in patients with thyroid carcinoma in our hospital.Material and methods: Retrospective study of 63 patients with thyroid car...

Objectives: The transition from the paediatric age to the adult is a particularly vulnerable period in patients with metabolic congenital diseases (mcd). In andalusia two adults’ units exist (seville and malaga) for the follow-up of these patients. Our aim in this study was to evaluate the current series of attended patients.Material and methods: We evaluated all patients transferred to the adult units since 2008. The clinical records were analyzed ...